ESMI Study Group on “Hyperpolarized Magnetic Resonance"

HYPER-MR

Scope, relevance, and objectives

Spin hyperpolarization has become a promising tool to study cellular, molecular and metabolic processes non invasively in vivo using magnetic resonance imaging (MRI) and spectroscopy (MRS). Biochemical processes can be monitored with hyperpolarized MRS, providing unique information on tissue metabolic and enzymatic activity. To date, dissolution-DNP and Parahydrogen techniques have attracted the most interest as methods to hyperpolarize small biomolecules in solution for potential clinical applications, and have been increasingly exploited for metabolic studies in vivo.

The applications of hyperpolarized MR have included studies of cancer and cardiac metabolism, from cell to translational large animal models. The University of California completed a 31-patient study performed by scientists at UCSF (published in 2013), while several sites in Europe and North America are preparing Phase 1 clinical trials using a clinic-ready version of the DNP hyperpolarizer.

Despite the growing importance of hyperpolarization technologies in biomedical and molecular imaging, there are still many challenging aspects for the scientific community that need to be addressed.

 

Objectives:

  • To foster new and integrated approaches in hyperpolarization technology, towards joint European initiatives.
  • To disseminate advances in the technologies and the applications of hyperpolarization for molecular imaging, inside and outside the imaging communities.
  • To support cooperative strategies among the European Hyperpolarization Community.